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*Salvia Price List – HERE
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Ordering Process – HERE
F.A.Q – HERE
Cancer Research & Cannabinoids Links – HERE
BCP Cannabinoids as a potential smoking cessation aid HERE
*Corona Virus: Potential Use of Cannabinoids to Treat Acute Respiratory Distress Syndrome & Cytokine Storm Associated with Coronavirus Disease – HERE
Contact: northlandsalvia@gmail.com
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*Extra Virgin Olive Oil OR VG – Vegetable Glycerine Base.
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CB.2RA 30x Liquid extract Cannabinoid Tincture, Oil, VG Juice, 500 ml & 1 Litre Liquid extract:
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” This is the first study to reveal the tissue and organ distribution of inhaled volatile BCP – β-caryophyllene (in animals. In a time-course analysis, BCP was detected in the brain, liver, and brown adipose tissue up to 24 h after exposure, indicating a long-lasting impact on these organs.
Results indicate that volatile BCP can affect metabolites via olfactory receptor-dependent pathways and that further studies are needed to clarify the effects of distributed volatile BCP in living organisms.
Detection of BCP in the brain is of particular interest: in general, only a limited number of functional food factors can be distributed to the brain. This is because the blood–brain barrier limits the transfer of substances from the blood to the brain.
Results indicate the possibility that inhaled volatile BCP might be distributed into the brain via blood circulation.
β-caryophyllene (BCP), a volatile bicyclic sesquiterpenoid has several bioactivities including anti-inflammatory, antioxidant, anti-carcinogenic, antibacterial, analgesic, local anesthetic, and lipid-lowering activities.
Gertsch et al. reported that BCP is a selective agonist of the cannabinoid receptor CB2, but not of CB1, and that it can be used for treating various diseases.
Essential oils have been used to regulate autonomic nervous activity, control depression, anxiety, cognitive disorders, insomnia, and stress-related disorders.
Studies conducted at various stages in vitro to in vivo, have suggested the pharmacological effects of inhaled components in essential oils.” Takemoto et al, 2021
NEW! CB.2RA dried herb extract: 5x, 10x, 15x, 20x, 30 x dried herb extract:
CB.2RA dried herb Extract Strength:
5x = extracted from 5 g of CB.2RA herbs.
10x = extracted from 10 g of CB.2RA herbs.
15x = extracted from 15 g of CB.2RA herbs.
20x = extracted from 20 g of CB.2RA herbs.
30x = extracted from 30 g of CB.2RA herbs.
*CB.2RA Dried Herb Extract Prices:
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‘Super Potentiated’ High Potency, 50 ml 30x CB2R.A Cannabinoid Extract Balm @ $42. *plus p & p
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Cannabinoids & Cancer Research Links – HERE
CB.2RA Cannabinoid Profile:
C.B 2 R.A – Cannabinoid Oil is a powerful, non psychoactive, all natural, plant based herbal extract, that targets the C.B 2 Cannabinoid Receptors, & may provide a legal alternative to ‘Prescription Only’ Cannabidiol (C.B.D) preparations, such as Tilray, Elixinol & Sativex.
There are many commercially available Cannabis preparations rich in beta Caryophyllene (BCP), including: Bedrocan®, Sativex®, Marinol®, Bedrobinol®, Namisol®, Arvisol®, Fenoxidol™, Epidiolex® etc. Hebaallah Mamdouh Hashiesh et al, 2021
beta Caryophyllene (BCP), a major component in Cannabis & some non Cannabis Plants, is classified as a dietary cannabinoid.
beta Caryophyllene (BCP) & its status as a ‘dietary cannabinoid’ DOES NOT have the Legal restrictions & Licensing requirements of cannabis.
At present, the only phytocannabinoid that has been discovered to also exist in plants other than Cannabis is beta Caryophyllene (BCP). Gertsch et al, 2010.
The phytocannabinoid BCP (beta Caryophyllene) has been identified as a fully selective agonist of CB2 cannabinoid receptors, one of the key members of the endocannabinoid system (ECS). Scandiffio et al 2020.
See Link@ Cannabis essential oils, Primary Terpenes found in popular Cannabis Strains.
The phytocannabinoid caryophyllene, also known as beta-caryophyllene or BCP, is crucial to not only the smell and taste of Cannabis, but also the medical benefits and different effects strains provide. There are over 100 known cannabinoids & terpenoids in the cannabis plant, but BCP is one of the most prominent.
BCP is a major constituent in Cannabis essential oil and shows significant cannabimimetic effects, it may also contribute to the overall effect of Cannabis preparations, including Sativex. Gertsch et al, 2008.
C.B 2 R.A – Cannabinoid Oil also contains the primary Terpenes: Myrcene, Linalool, Pinene, Humulene, Trans-nerolidol, & more!
Our C.B 2 R.A – Cannabinoid Oil is sourced from natural Whole Plant Extracts, Organically Grown & prepared by us, rich in the phytocannabinoid beta Caryophyllene (BCP) & Terpenes.
Our source Plants, native to the Americas, have one of the highest beta Caryophyllene profiles in the Plant Kingdom!
β-caryophyllene (BCP) activity on human CB2 Cannabinoid Receptors, has a binding affinity (pKi) value of 155 nM with a lack of substantial affinity for CB1R. Hashiesh et al 2021.
To compare CB2R binding, β-Caryophyllene has the highest CB2 cannabinoid activity. Cannabinol (CBN) binds to the CB2 receptors as a partial agonist with a binding affinity of CB2 Ki at 126.4 nM[9] while Delta-9-Tetrahydrocannabinol (THC) binds to the CB2 receptors as a partial agonist with an affinity of Ki at 36nM.[10]
C.B 2 R.A – Cannabinoid Oil is NON PSYCHOACTIVE, contains NO prohibited or restricted substances, & has been identified as a C.B 2 Receptor Agonist.
C.B 2 R.A – Cannabinoid Oil DOES NOT activate the CB1 Receptors, which are responsible for the ‘High” associated with Cannabis sativa & indica.
C.B 2 R.A – Cannabinoid Oil DOES activate the CB2 Receptors, providing analgesic, sedative & anti inflammatory effects.
CB2R.A may assist overall health & wellbeing, by boosting the Immune System, via the E.C.S – Endocannabinoid System & thereby achieving a state of Homeostasis.
More information on the E.C.S – Endocannabinoid System & phyto-cannabinoids HERE
Cannabinoid Dosing Methods & Bioavailability Rates: HERE
Cannabinoid type 2 receptor (CB2R)-mediated pharmacological activities and therapeutic potential of β-caryophyllene (BCP): Source: HERE
The Cannabinoid BCP beta Caryophyllene: an attractive compound for chronic pain (both inflammatory and neurogenic):
The Cannabinoid BCP beta Caryophyllene is an attractive compound for chronic pain (both inflammatory and neurogenic) due to its direct action on CB2R (Cannabinoid 2 Receptor) without creating a tolerance, as demonstrated in an animal model of neuropathic pain.
Remarkably, the researchers concluded that the effect of BCP became stronger during the treatment period. Scott A. Johnson et al, 2020.
This is significant considering drug tolerance after prolonged use is observed with other analgesic therapies and may require increased dosage, which may accelerate tolerance and further reduce the effects of a therapeutic substance.
BCP exerts potent anti-inflammatory effects when taken orally, which may be explained by its ability to simultaneously inhibit pathways (toll-like receptor complex CD14/TLR4/MD2) that increase the production of proinflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-⍺), reduce immune-related inflammation, and synergize the µ-opioid receptor pathways.
Preclinical models demonstrate that BCP can reduce inflammation in a variety of bacterial-caused, eosinophil-related, and neuropathic inflammatory conditions.
It can also enhance the effects of other pain medications like morphine, making it a promising candidate to reduce effective drug dose and therefore potential drug dependence and tolerance.
In this way, it modulates pain signaling pathways in a manner that may enhance, and not compete with, the benefits of other pain-or inflammation-relieving substances. Scott A. Johnson et al, 2020.
” while all attempts are being focused on control of viral replication through development of vaccines, it is also critical to ensure that the vaccines do not trigger hyperactivation of immune response.
It is equally important to develop new anti-inflammatory therapies that can effectively block the cytokine storm seen in patients with severe form of COVID-19.
We believe that cannabinoids hold significant promise as potent anti-inflammatory agents.”
” BCP (beta Caryophyllene) may be a promising candidate as a preventive and therapeutic agent or adjuvant for COVID-19 given its pharmacological and molecular mechanisms, including its CB2R agonist property, integrating with its antiviral, anti-inflammatory, and immunomodulatory properties in numerous experimental studies” (Sharma et al., 2016).
Freshly harvested, organic BCP Buds. Rich in the Cannabinoid beta Caryophyllene (BCP) & Terpenes.
Our C.B 2 R.A – 30x Cannabinoid Oil: is available as:
an Olive Oil based liquid extract.
a Vegetable Glycerine (V.G) based liquid extract.
a herbal tincture.
a VG-juice.
50 ml 30x Extract Balm, natural Coconut base.
Introductory offer:
NEW! 5 ml Sampler 30x CB2R.A Cannabinoid Oil, dropper bottle, @ $25. *plus $10. p & p *Parcel Collect
‘Super Potentiated’ High Potency, 20 ml 30x CB2R.A Cannabinoid Oil @ $99. *plus $10. p & p. *Parcel Collect
‘Super Potentiated’ High Potency, 100 ml 30x CB2R.A Cannabinoid Oil @ $399. *plus $10. p & p. *Parcel Collect *Special* +FREE Post Save $
*Bulk Buy & Save! 500 ml & 1 Litre bottles of all our liquid extract herbal remedies range, available at Competitive Prices. Prices on enquiry. Ts & Cs Apply.
‘Super Potentiated’ High Potency, 50 ml 30x CB2R.A Cannabinoid Balm @ $42. *plus $10. p & p. *Parcel Collect
Ordering Process – HERE
F.A.Q – HERE
Contact: northlandsalvia@gmail.com
*Payment via Online banking.
Research Links:
See: Beta-caryophyllene is a dietary cannabinoid.
” (E)-BCP is the first Cannabis-derived functional CB receptor ligand with a fundamentally different structure from the classical cannabinoids. Thus, it represents a new type of CB2 receptor-selective agonist that is based on an unusual cyclobutane-containing scaffold.”
” BCP is a major constituent in Cannabis essential oil and shows significant cannabimimetic effects, it may also contribute to the overall effect of Cannabis preparations, including Sativex.”
See: Phytocannabinoids beyond the Cannabis plant.
‘ At present, the only phytocannabinoid that has been discovered to also exist in plants other than Cannabis is b-caryophyllene (BCP), which is among the most abundant plant essential oil components……
b-caryophyllene, (BCP) which is also one of the most abundant secondary metabolites in Cannabis essential oil, could be considered as a true CB2 receptor-selective Cannabis constituent.’
See: Cannabimimetic phytochemicals in the diet – an evolutionary link to food selection and metabolic stress adaptation?
‘ The best studied phytochemical is β‐caryophyllene (BCP), which has been independently shown to exert numerous CB2receptor‐mediated cannabimimetic effects……’
See: β -caryophyllene and β -caryophyllene oxide – natural compounds of anticancer and analgesic properties.
” BCP is a phytocannabinoid with strong affinity to cannabinoid receptor type 2 (CB2 ) but not cannabinoid receptor type 1 (CB1 ). …the double activity of BCP, anticancer and analgesic, as well as its beneficial influence on the efficacy of classical chemotherapeutics, is particularly valuable in oncology. “
*Full version pdf HERE
” Although the pancreatic tumor biopsies and cell lines analyzed expressed both CB1 and CB2 cannabinoid receptors, our findings indicate that the CB2 receptor is the one that plays a major role in the proapoptotic effect of cannabinoids in these cells.”
See: Beta-caryophyllene a CB2 receptor agonist, produces multiple behavioural changes relevant to anxiety & depression.
” preclinical results suggest that CB2 receptors may provide alternative therapeutic targets for the treatment of anxiety and depression. The possibility that BCP may ameliorate the symptoms of these mood disorders offers exciting prospects for future studies. “
See: β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis
” (this) study represents significant implications for clinical research and strongly supports the effectiveness of BCP as a novel molecule to target in the development of effective therapeutic agents for MS. “
See: New insights in the antitumor effects of β-caryophyllene in breast cancer cells: The role of cannabinoid and adrenergic systems
” Caryophyllene (CRY) was found able to significantly inhibit the growth of MDA-MB-468 cells….. Data obtained highlight antiproliferative properties of Caryophyllene (CRY) in triple negative breast cancer, with a possible β2-adrenergic system contribution.
CRY acts partly by a CB2- activation, although other CB1/CB2 independent mechanisms appear involved. CRY also interferes with smoking-induced progression and metastatization of breast cancer cells: this effect can be approached as a chemopreventive strategy in breast oncologic patients. Present results encourage further studies on CRY as chemopreventive agent or in targeted supporting therapies for breast cancer.
See: Clinical Endocannabinoid Deficiency
” studies have provided a firmer foundation for the theory, while clinical data have also produced evidence for decreased pain, improved sleep, and other benefits to cannabinoid treatment and adjunctive lifestyle approaches affecting the ECS.”
See: Therapeutic Potential of Caryophyllene: A Dietary Cannabinoid in Diabetes & Associated Complications
‘ Given the safe status, abundant natural occurrence, oral bioavailability, dietary use and pleiotropic properties modulating receptors and enzymes, BCP appears as a promising molecule for diabetes and its complications.’
For enquiries contact:
northlandsalvia@gmail.com
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More info re Cannabinoids & Terpenes HERE
Ordering Process – HERE
F.A.Q – HERE
Dr Hill & Dr Osguthorpe discuss CBD vs beta Caryophyllene, the major constituent in Copaiba.
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