” Cancer is a disease of deregulated cellular behavior.
Acquisition of oncogenic attributes, loss of tumor suppressive functions, evasion of physiological tissue architecture and interactions with the cellular microenvironment enable malignant cells to escape the mechanisms of normal cellular homeostasis in an organism.
Cancer cells are therefore able to sustain unlimited proliferation, to thrive under conditions that preclude normal cell survival, and to spread to distant sites through the process of metastasis.
Natural products are important sources of new anticancer drugs, new drug leads and new chemical entities.” ( Haque et al, 2015 )
How Cancer Spreads explains the process of metastasis. Once metastatic cells are attached to the basement membrane (a physical barrier that separates tissue components), they break through with the help of an enzyme called type IV collagenase.
Cancer cells then move through the blood stream enabling them to spread to other parts of the body. A secondary tumor may form at another site in the body. Jane Hurd (Illustrator) National Cancer Institute
Many investigations have been made to establish the potential utility of cannabinoids in cancer therapies.
Currently, it is believed that all anticancer activities of cannabinoids may be based on three different mechanisms: (1) induction of apoptosis 25, (2) repression of cell cycle 26, and (3) inhibition of angiogenesis and metastasis 27.
Globally, Australia tops the list of countries with the highest number of cancer rates, followed by New Zealand and Ireland (Sagbo et al, 2021)
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Anticancer and analgesic activities of Cannabinoid β-caryophyllene (BCP):
Research Links:
See: β -caryophyllene and β -caryophyllene oxide – natural compounds of anticancer and analgesic properties. Cancer: Colon Cancer, Breast Cancer, Cervical Cancer, Pancreatic Cancer, Lymphoma, Melanoma, Brain Cancer, et al.
See: New insights in the antitumor effects of β-caryophyllene in breast cancer cells: The role of cannabinoid and adrenergic systems. Breast Cancer.
See: Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes. Pancreatic Cancer.
See: β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models. Colorectal Cancer. Full Text HERE
See: The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllene from the Essential Oil of Aquilaria crassna. Colorectal Cancer.
See: Beta-Caryophyllene Suppresses Ovarian Cancer Proliferation by Inducing Cell Cycle Arrest and Apoptosis. Ovarian Cancer.
See: β-Caryophyllene Inhibits Cell Proliferation through a Direct Modulation of CB2 Receptors in Glioblastoma Cells. Brain Cancer.
See: β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway – An in-vitro and in-silico study. Cancer: Inhibition mechanism by which the Cannabinoid BCP beta Caryophyllene suppresses cancer cell proliferation and enhances apoptosis.
See: β-Caryophyllene: A Sesquiterpene with Countless Biological Properties for the treatment of many pathological conditions, including tumours (colon, breast, pancreas, lymphoma, melanoma and glioma cancer). Cancer: Colon Cancer, Breast Cancer, Pancreatic Cancer, Lymphoma, Melanoma, Brain Cancer.
See: Chronic cannabinoid CB2 activation reverses paclitaxel neuropathy without tolerance or CB1-dependent withdrawal. Cancer: CB2 Activation Reverses Neuropathy Side Effects from Paclitaxel ( Taxol ) Cancer Therapy.
See: Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel (Taxol) Paclitaxel (Taxol) Chemotherapy Medication for: Ovarian, Breast, Lung, Bladder, Prostate, Melanoma, Esophageal, and other types of solid tumor cancers as well as Kaposi’s sarcoma.
See: Inhibitory Effects of β-Caryophyllene on Helicobacter pylori Infection In Vitro and In Vivo (Gastric Cancer) Gastric Cancer.
See: Beta Caryophyllene and Caryophyllene Oxide, Isolated from Aegle Marmelos, are Potent Anti-inflammatory Agents against Lymphoma and Neuroblastoma Cells. Full Text HERE Cancer: Lymphoma and Neuroblastoma Cells. *Neuroblastoma Cells.)
See: Chemosensitizing Properties of β-Caryophyllene and β-Caryophyllene Oxide in Combination with Doxorubicin in Human Cancer Cells Cancer: Enhancing properties of the Cannabinoid BCP Caryophyllene in Doxorubicin chemotherapy for breast cancer, bladder cancer, Kaposi’s sarcoma, lymphoma, and acute lymphocytic leukemia.
See: β-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (Commiphora gileadensis), Is a Selective Apoptosis Inducer for Tumor Cell Lines. Cancer. The Cannabinoid BCP Caryophyllene is an apoptosis inducer that acts, in a selective manner, against tumor cell lines and not against normal cells.
See: The endocannabinoid system and cancer: therapeutic implication Breast, Prostate and Bone Cancers.
See: The Endocannabinoid System: A Target for Cancer Treatment Gastrointestinal Cancers, Lung Cancer, Breast and Prostate Cancers, Pancreatic and Thyroid Cancers, Brain Cancer.
See: Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence. Cancer: Emerging evidence have highlighted a complex pool of healing properties, including a block of carcinogen-mediated DNA damage and cytoprotection against anticancer drug toxicity in noncancerous cells, along with antiproliferative and chemosensitizing activitives in cancer cells, thus suggesting their promising role as chemopreventive agents.
See: BCP modulates multiple pathways involved in cancer pathogenesis including MAPK, PI3K/AKT/mTOR/S6K1, and STAT3 , activates cytotoxic pathways against tumors, potentiates pathways that hinder metastasis, reduces the expression of oncogenes and proteins, and simultaneously increases genes and proteins that destroy cancer cells. Laboratory studies suggest the Cannabinoid BCP (beta Caryophyllene) has promise against kidney, lung, colorectal, liver, oral, melanoma, leukemia, lymphoma, and neuroblastoma cancers and possesses chemopreventive properties. Source: A Systematic Review of Essential Oils and the Endocannabinoid System: A Connection Worthy of Further Exploration. Editor: Tadaaki Satou
See: Beta-caryophyllene is a dietary cannabinoid.
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Therapeutic Potential of Salvia divinorum (SA)
KOR agonists such as Salvia divinorum (SA) have applications for multiple ailments, and SA is extremely affine, potent, and precise when it comes to binding to these brain receptors. Some of the valuable medications that could be developed from S. divinorum include:
Medications to treat different types of cancer: When there are tumors in the
brain, one of the difficulties of therapeutics is to get the drugs through the
blood-brain barrier and reach the tumor.
The terpene SA is able to cross the blood-brain barrier and reach the brain and structures of the CNS in less than a minute.
SA analogs have demonstrated antiproliferative properties, inhibiting
the growth of 77–86% of tumor cells in breast cancer (Vasiljevik, Groer,
Lehner, Navarro, & Prisinzano, 2014). Source: Ana Elda Maqueda
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