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We are advocates of the medicinal benefits of Salvia divinorum herb and its use in herbal remedies.
We believe the treatment of illness has been influenced by the Pharmaceutical Companies, primarily on the basis of generating profit from their ‘industry’ packaged products.
Many of these ‘synthesized end products’ may have consequential side effects which undermine their purported benefits. We only need look to the release of approved pharmaceutical products deemed safe, only to be withdrawn due to unintended consequences once they have gone to market.
Much of the Pharmaceutical Companies’ focus is on maintenance drugs that mask the symptoms of illness, rather than treating the source of the problem.
The selective synthesis of individual Plant constituents on the basis of economy, profit margins and patent protections, means that many of the other beneficial, active constituents, naturally contained in the Whole Plant, are ‘lost’ in the synthetic production process.
Anecdotal evidence suggests that Salvia divinorum herb has many potential therapeutic uses & has a rich history of medicinal use as a herbal remedy, by the indigenous Mazatec of Oaxaca, Mexico.
Potential therapeutic uses may include: an anti depressant, anti anxiety, anti addiction treatment, a powerful painkiller, anti inflammatory, muscle relaxant, mood stabilizer, treatment for Irritable Bowel Syndrome, Post Traumatic Stress Disorder, Neurological Disorders, Alzheimers Disease, & more!
Salvinorin A
*LINKS:
Neuropharmacology of the Naturally Occurring κ-Opioid,Salvinorin A.
” S. divinorum has advanced from being a tool for divination rituals to being a source of therapeutic potential for the treatment of gastrointestinal disorders, pain, stimulant dependence, and mood disturbances. “
Salvia divinorum – From Party Drug to Anti-Addiction Treatment
” S. divinorum has potential for use as an anti addiction treatment ….. in the future it may be possible to add a kappa opioid-based compound to prescription pain medication to help avoid the addiction that is a side-effect of their use.”
Salvinorin A & related compunds as therapeutic drugs for psycho stimulant related disorders.
” … reviewed studies indicate that κ agonists decrease dopamine neurotransmission, possibly by decreasing dopamine release and increasing its uptake. Thus, these compounds could be beneficial for patients suffering stimulant-related disorders.
Salvinorin A and its analogues show anti-addictive effects in several animal studies using psychostimulants as the drug under investigation.
Further studies are warranted on the anti-addictive potentials of salvinorin A and its analogues. ” *The original, full, free PDF is now pay per view/purchase.
The Kappa Opioid Receptor: A Promising Therapeutic Target for Multiple Pathologies.
Within the drug-development field KOR agonists (*Salvia divinorum is a natural Plant KOR agonist) have been extensively investigated for the treatment of many centrally mediated nociceptive disorders including pruritis (itching) and pain.
KOR agonists are potential alternatives to mu-opioid receptor (*MOR) agonists for the treatment of pain due to their anti-nociceptive effects, lack of abuse potential, and reduced respiratory depressive effects………..
Other diseases for which KOR agonists hold promising therapeutic potential include pruritis (itching), multiple sclerosis, Alzheimer’s disease, inflammatory diseases, gastrointestinal diseases, cancer, and ischemia.
*μ-opioid receptors (MOR) are a class of opioid receptors, also referred to as μ(mu)-opioid peptide (MOP) receptors e.g, Morphine, Methadone, Fentanyl, are μ-opioid receptor agonists.
The Use of Salvia divinorum from a Mazatec Perspective
The Mazatec people have been using the leaves for centuries in ceremonies…….. as a treatment for arthritis and inflammation, gastrointestinal problems, headaches, and addictions, among other uses.
The active principle of Salvia divinorum, the terpene salvinorin A, is a uniquely potent and highly selective kappa-opioid receptor agonist and, as such, has enormous potential for the development of valuable medications.
Among them, the most promising include safe and nonaddictive analgesics, neuroprotectors, short-acting anesthetics that do not depress respiration, antidepressants, anti-inflammatories, medications for the treatment of addiction to stimulants and alcohol, and drugs to treat disorders characterized by alterations in perception.
Therapeutic Potential of Salvinorin A and Its Analogues in Various Neurological Disorders
” Despite its short duration of action, a single dose of salvinorin A, induces rapid and robust changes in the patterns of neural activity and connectivity in disease-related neuronal circuits. While not fully understood, these neurophysiological effects might explain salvinorin A’s rapid and durable therapeutic effects in neuropsychiatric disorders that are difficult to treat.
Furthermore, the unique chemical structure of salvinorin A provides a useful backbone for chemists to develop novel compounds targeting KOR and other opioid receptors for structure-activity relationships, structure-function analyses, and novel medication design purposes “
Salvia divinorum: Clinical & Research Potential (RE Depression)
“… initial results are promising, with the majority of patients reporting lasting benefits from their use of this herb. In addition to significantly reduced scores on quantitative measures of depression, some of the reported benefits of the herb include mood enhancement and increased feelings of relaxation and self-awareness.”
Revixia Life Sciences, an entity of clinical-stage biopharmaceutical company atai Life Sciences, is developing a proprietary formulation of Salvinorin A, RLS-01, as a medication for treatment-resistant depression. (The Bloom, 2024)
“SalA is a substance derived from Salvia divinorum. SalA is a unique non-nitrogenous agonist of the kappa-opioid receptor (KOR) with potential use in treatment-resistant depression (TRD), substance use disorder (SUD) and pain.” (Revixia Life Sciences, 2024)
Antinociceptive effects of Salvia divinorum and bioactive salvinorins in experimental pain model
“S. divinorum extract produced a dose-dependent antinociceptive effect at central and peripheral levels in pain models. The effect of the extract was observed due to the presence of salvinorins, mainly salvinorin A. Antinociceptive effect of S. divinorum involved both the serotonin 5-HT1A and opioids receptors as inhibitory neurotransmission depending on the type of nociception.”
*antinociceptive = the action or process of blocking the detection of a painful or injurious stimulus by sensory neurons.
Salvia divinorum is unique! *A previous study of 441 Salvia species from many regions, found plant derived salvinorin A was present only in the Plant Salvia divinorum, from Mexico. Bodnar-Willard et al, 2020.
Salvia divinorum dried herbal Extract, Salvia Liquid Extract & Natural Salvia Leaves: HERE
” Salvia divinorum is a unique, sometimes puzzling herb, that is accorded Sacred Reverence by the Indigenous Mazatec of Oaxaca Mexico, who view Her as the embodiment of St Mary. She has the ability, with patience, respect, commitment & honest intention, to yield life changing shifts in the physical, spiritual, emotional wellbeing of those who embrace her. “ (NorthlandSalvia, 2024)
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